The cystic endometrial hyperplasia complex is an alteration of the uterus of bitches and queens. It is directly related to the repeated exposition or drawn out of hormones estrogen and progesterone. It is characterized by an exaggerated response along the production and release of the secretion of the endometrial glands and dependent on the degree of hydratation and present protein in this secretion, the alteration could be considered hydrometra or mucometra. Pyometra is considered when due to individual factors or because of virulence and proliferation of invading bacteria in the fluid causing other secondary signs and symptoms that can provoke death of the patient.